Anadrol

Oxymetholone 25mg, one of the strongest oral anabolic’s available. Known for explosive strength, rapid size gains and intense pumps, Anadrol 25mg is for experienced users chasing serious growth.

Anadrol – Harm Reduction Crib Sheet

Compound: Oxymetholone
Class: Oral Anabolic-Androgenic Steroid (AAS), Dihydrotestosterone (DHT) derivative
Administration: Oral

Dosage

• Performance Use: 25–50 mg/day
• Advanced Use: Up to 100 mg/day (not recommended for harm reduction)
• Cycle Length: 2–4 weeks recommended (high liver strain)

Half-Life

• ~8 to 9 hours
• Dosing: Once daily or split into 2 doses (morning/evening)

Benefits

• Rapid and significant increases in size, weight and strength
• Strong appetite stimulation (in some users)
• No aromatisation – does not convert to oestrogen
• Very effective in short cycles or as a jump-start compound

Side Effects

• Hepatotoxicity: High risk due to 17α-alkylated structure
• Oestrogenic-like effects: Bloating, gynecomastia, water retention (despite no aromatisation)
• Androgenic: Acne, oily skin, hair loss
• Suppression: Severe inhibition of natural testosterone production
• Lipid impact: Profound ↓ HDL, ↑ LDL
• Appetite suppression and lethargy in some users

Risks

• Liver toxicity: Elevated ALT/AST, potential hepatotoxicity, cholestasis
• Cardiovascular strain: Significant due to lipid shifts and water retention
• Hypertension: Common with high doses due to fluid retention
• Endocrine disruption: Profound HPTA suppression
• Reproductive: Infertility and testicular atrophy
• Psychological: Potential mood swings, aggression, fatigue

Risk Mitigation

• Bloodwork: Liver enzymes, lipids, CBC, TT/FT, E2 pre-, mid-, and post-cycle
• Cycle support: TUDCA (250–500 mg/day), NAC, hydration, no alcohol
• Monitor BP: Regular checks due to fluid retention
• Lipid support: Omega-3s, fibre, red yeast rice
• Limit duration: 2–4 weeks only
• Test base: Strongly advised to maintain function and mitigate lethargy

Post-Cycle Therapy (PCT)

If not transitioning to TRT

• Start: 1–2 days after last dose
• Tamoxifen (Nolvadex):
  • 40 mg/day (Weeks 1–2)
  • 20 mg/day (Weeks 3–4)
• Optional – Clomiphene (Clomid): 50 mg/day for 4 weeks
• Follow-up labs: 4–6 weeks post-PCT